Vitoss BA Bioactive Bone Graft Substitute

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Vitoss BA Bioactive Bone Graft Substitute
Category: Biomaterials

A synthetic bone graft with bioactive glass that has a unique porosity, structure, and chemistry to help drive 3D regeneration of bone


Literature has shown that bioactive glass exhibits good bonding-to-bone properties in animal models.1-3 Upon implantation, the ionic constituents (Silicon, Sodium, and Calcium) of bioactive glass are released into the surrounding environment and react with bodily fluids.4-7 This reaction produces the deposition of a thin layer of physiologic calcium phosphate at its surface, favorable for osteoblast attachment.8 This is commonly referred to as a bioactive effect, and may lead to the bonding of new bone to the scaffold.1-3,6,9-11 Vitoss BA is a highly porous calcium-phosphate (up to 90% porous)12 containing bioactive glass that is stable at physiological pH13 and resorbs during the natural remodeling process of bone.14

  • The addition of bioactive glass helps create a surface favorable for osteoblast attachment1-3,6,9-11
  • Vitoss BA Foam Pack is stable in a fluid environment, can soak and hold bone marrow, and is moldable
  • Vitoss BA Foam Strip is flexible when wet, can soak and hold bone marrow, and is compression resistant and easy to cut
Note: In-vitro bioactivity testing has not been evaluated in human clinical trials.
  1. Hench, L.L., Splinter, R.J., and Allen, W.C., Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials. Journal of Biomedical Materials Research, 1971; 2(1): 117-141.
  2. Hench, L.L., Paschall, H.A., Direct Chemical Bond of Bioactive Glass-Ceramic Materials to Bone and Muscle. Journal of Biomedical Materials Research, 1973; 4: 25-42.
  3. Gross, U., The Interface of Various Glasses and Glass Ceramics with a Bony Implantation Bed. Journal of Biomedical Materials Research, 1985; 19: 251-271.
  4. Hench, L.L. The Story of Bioglass. Journal of Materials Science: Materials in Medicine, 2006 Nov; 17(11): 967-78.
  5. Oonishi, H., et al., Particulate Bioglass Compared with Hydroxyapatite as a Bone Graft Substitute. Clinical Orthopaedics and Related Research, 1997 Jan; 334: 316-25.
  6. Vrouwenvelder, W.C.A., Histological and Biochemical Evaluation of Osteoblasts Cultured on Bioactive Glass, Hydroxylapatite, Titanium Alloy, and Stainless Steel. Journal of Biomedical Materials Research, 1993 Apr; 27(4): 465-75.
  7. Xynos, I.D., Edgar, A.J., Buttery, L.D.K., Hench, L.L., and Polak, J.M., Ionic Products of Bioactive Glass Dissolution Increase Proliferation of Human Osteoblasts and Induce Insulin-like Growth Factor II mRNA Expression and Protein Synthesis. Biochemical and Biophysical Research Communications. 2000 Sep 24;276(2):461-5.
  8. Hench, L.L., Polak, J.M., Xynos, I.D., Buttery, L.D.K., Bioactive Materials to Control Cell Cycle. Materials Research Innovations, 2000; 3(6): 313-323.
  9. Sanders, D.M., Hench, L.L., Mechanisms of Glass Corrosion. Journal of American Ceramic Society.1973; 56(7): 373-377.
  10. Hench, L.L., Characterization of Glass Corrosion and Durability. Journal of Non-Crystalline Solids, 1975; 19: 27-39.
  11. Ogino, M., Hench, L.L., Formation of Calcium Phosphate Films on Silicate Glasses. Journal of Non-Crystalline Solids, 1980; 38 and 39: 673-678.
  12. Stryker Spine Test Report P/N 1070-0008R
  13. Rey C, Combes C, Drouet C, Grossin D. (2011). Bioactive Ceramics - Physical Chemistry. In Ducheyne, Paul. Comprehensive Biomaterials. 1. Elsevier. pp. 187–281. 
  14. Anker et al, Ultraporous Beta-Tricalcium Phosphate is Well Incorporated in Small Cavitary Defects. Clinical Orthopaedics and Related Research, 2005 May; 434: 251-7.

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